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Chembridge commercial library express pick stock
Commercial Library Express Pick Stock, supplied by Chembridge, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/express-pick+library/commercial+express+library+pick+stock/pmc12894705-157-17-22
Average 86 stars, based on 1 article reviews
commercial library express pick stock - by Bioz Stars, 2026-10
86/100 stars

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High Throughput Screening Assay:

Article Title: Actives-Based Receptor Selection Strongly Increases the Success Rate in Structure-Based Drug Design and Leads to Identification of 22 Potent Cancer Inhibitors.
Article Snippet: Computer-aided drug design, an important component of the early stages of the drug discovery pipeline, routinely identifies large numbers of false positive hits that are subsequently confirmed to be experimentally inactive compounds.. We have developed a methodology to improve true positive prediction rates in structure-based drug design and have successfully applied the protocol to twenty target systems and identified the top three performing conformers for each of the targets.. Receptor performance was evaluated based on the area under the curve of the receiver operating characteristic curve for two independent sets of known actives.

Article Title: Targeting Troponin C with Small Molecules Containing Diphenyl Moieties: Calcium Sensitivity Effects on Striated Muscles and Structure-Activity Relationship.
Article Snippet: Despite large investments from academia and industry, heart failure, which results from a disruption of the contractile apparatus, remains a leading cause of death.. Cardiac muscle contraction is a calcium-dependent mechanism, which is regulated by the troponin protein complex (cTn) and specifically by the N-terminal domain of its calcium-binding subunit (cNTnC).. There is an increasing need for the development of small molecules that increase calcium sensitivity without altering the systolic calcium concentration, thereby strengthening the cardiac function.

Article Title: Rational design of drug-like compounds targeting Mycobacterium marinum MelF protein
Article Snippet: The ChemBridge Core library and Express-Pick Library are two mutually exclusive libraries of commercially available small drug-like compounds at the Hit2Lead.com online store of ChemBridge site.

Article Title: Discovery of Nanomolar Inhibitors for Human Dihydroorotate Dehydrogenase Using Structure-Based Drug Discovery Methods.
Article Snippet: We used a structure-based drug discovery approach to identify novel inhibitors of human dihydroorotate dehydrogenase (DHODH), which is a therapeutic target for treating cancer and autoimmune and inflammatory diseases.. In the case of acute myeloid leukemia, no previously discovered DHODH inhibitors have yet succeeded in this clinical application.. Thus, there remains a strong need for new inhibitors that could be used as alternatives to the current standard-of-care.

Article Title: Development of a High-Throughput Biochemical Assay to Screen for Inhibitors of Aerobactin Synthetase IucA
Article Snippet: Larger-scale screening campaigns included the EXPRESS-Pick library (ChemBridge (CB) Corp., San Diego, CA) and the HitDiscover collection (Maybridge (MB), Thermo Fisher Scientific, Waltham, MA).

Article Title: Bacterial Cytological Profiling Identifies Rhodanine-Containing PAINS Analogs as Specific Inhibitors of Escherichia coli Thymidylate Kinase In Vivo .
Article Snippet: A synthetic small molecule library consisting of ;1,800 compounds was obtained from the ChemBridge EXPRESS-pick library stock collection and screened in 96-well plates at 100mg/ml in Luria-Bertani (LB) medium to identify compounds active against the E. coli DtolC mutant.

Article Title: Targeting Troponin C with Small Molecules Containing Diphenyl Moieties: Calcium Sensitivity Effects on Striated Muscle and Structure Activity Relationship
Article Snippet: We focused on two small molecule libraries from ChemBridge, the EXPRESS-Pick Library and Core Library, and filtered each library with a cheminformatics approach as described in the section.

Filtration:

Article Title: Actives-Based Receptor Selection Strongly Increases the Success Rate in Structure-Based Drug Design and Leads to Identification of 22 Potent Cancer Inhibitors.
Article Snippet: Computer-aided drug design, an important component of the early stages of the drug discovery pipeline, routinely identifies large numbers of false positive hits that are subsequently confirmed to be experimentally inactive compounds.. We have developed a methodology to improve true positive prediction rates in structure-based drug design and have successfully applied the protocol to twenty target systems and identified the top three performing conformers for each of the targets.. Receptor performance was evaluated based on the area under the curve of the receiver operating characteristic curve for two independent sets of known actives.

Article Title: Targeting Troponin C with Small Molecules Containing Diphenyl Moieties: Calcium Sensitivity Effects on Striated Muscles and Structure-Activity Relationship.
Article Snippet: Despite large investments from academia and industry, heart failure, which results from a disruption of the contractile apparatus, remains a leading cause of death.. Cardiac muscle contraction is a calcium-dependent mechanism, which is regulated by the troponin protein complex (cTn) and specifically by the N-terminal domain of its calcium-binding subunit (cNTnC).. There is an increasing need for the development of small molecules that increase calcium sensitivity without altering the systolic calcium concentration, thereby strengthening the cardiac function.

Article Title: Rational design of drug-like compounds targeting Mycobacterium marinum MelF protein
Article Snippet: The ChemBridge Core library and Express-Pick Library are two mutually exclusive libraries of commercially available small drug-like compounds at the Hit2Lead.com online store of ChemBridge site.

Article Title: Discovery of Nanomolar Inhibitors for Human Dihydroorotate Dehydrogenase Using Structure-Based Drug Discovery Methods.
Article Snippet: We used a structure-based drug discovery approach to identify novel inhibitors of human dihydroorotate dehydrogenase (DHODH), which is a therapeutic target for treating cancer and autoimmune and inflammatory diseases.. In the case of acute myeloid leukemia, no previously discovered DHODH inhibitors have yet succeeded in this clinical application.. Thus, there remains a strong need for new inhibitors that could be used as alternatives to the current standard-of-care.

Article Title: Development of a High-Throughput Biochemical Assay to Screen for Inhibitors of Aerobactin Synthetase IucA
Article Snippet: Larger-scale screening campaigns included the EXPRESS-Pick library (ChemBridge (CB) Corp., San Diego, CA) and the HitDiscover collection (Maybridge (MB), Thermo Fisher Scientific, Waltham, MA).

Article Title: Bacterial Cytological Profiling Identifies Rhodanine-Containing PAINS Analogs as Specific Inhibitors of Escherichia coli Thymidylate Kinase In Vivo .
Article Snippet: A synthetic small molecule library consisting of ;1,800 compounds was obtained from the ChemBridge EXPRESS-pick library stock collection and screened in 96-well plates at 100mg/ml in Luria-Bertani (LB) medium to identify compounds active against the E. coli DtolC mutant.

Article Title: Targeting Troponin C with Small Molecules Containing Diphenyl Moieties: Calcium Sensitivity Effects on Striated Muscle and Structure Activity Relationship
Article Snippet: We focused on two small molecule libraries from ChemBridge, the EXPRESS-Pick Library and Core Library, and filtered each library with a cheminformatics approach as described in the section.

Binding Assay:

Article Title: Actives-Based Receptor Selection Strongly Increases the Success Rate in Structure-Based Drug Design and Leads to Identification of 22 Potent Cancer Inhibitors.
Article Snippet: Computer-aided drug design, an important component of the early stages of the drug discovery pipeline, routinely identifies large numbers of false positive hits that are subsequently confirmed to be experimentally inactive compounds.. We have developed a methodology to improve true positive prediction rates in structure-based drug design and have successfully applied the protocol to twenty target systems and identified the top three performing conformers for each of the targets.. Receptor performance was evaluated based on the area under the curve of the receiver operating characteristic curve for two independent sets of known actives.

Article Title: Targeting Troponin C with Small Molecules Containing Diphenyl Moieties: Calcium Sensitivity Effects on Striated Muscles and Structure-Activity Relationship.
Article Snippet: Despite large investments from academia and industry, heart failure, which results from a disruption of the contractile apparatus, remains a leading cause of death.. Cardiac muscle contraction is a calcium-dependent mechanism, which is regulated by the troponin protein complex (cTn) and specifically by the N-terminal domain of its calcium-binding subunit (cNTnC).. There is an increasing need for the development of small molecules that increase calcium sensitivity without altering the systolic calcium concentration, thereby strengthening the cardiac function.

Article Title: Rational design of drug-like compounds targeting Mycobacterium marinum MelF protein
Article Snippet: The ChemBridge Core library and Express-Pick Library are two mutually exclusive libraries of commercially available small drug-like compounds at the Hit2Lead.com online store of ChemBridge site.

Article Title: Discovery of Nanomolar Inhibitors for Human Dihydroorotate Dehydrogenase Using Structure-Based Drug Discovery Methods.
Article Snippet: We used a structure-based drug discovery approach to identify novel inhibitors of human dihydroorotate dehydrogenase (DHODH), which is a therapeutic target for treating cancer and autoimmune and inflammatory diseases.. In the case of acute myeloid leukemia, no previously discovered DHODH inhibitors have yet succeeded in this clinical application.. Thus, there remains a strong need for new inhibitors that could be used as alternatives to the current standard-of-care.

Article Title: Development of a High-Throughput Biochemical Assay to Screen for Inhibitors of Aerobactin Synthetase IucA
Article Snippet: Larger-scale screening campaigns included the EXPRESS-Pick library (ChemBridge (CB) Corp., San Diego, CA) and the HitDiscover collection (Maybridge (MB), Thermo Fisher Scientific, Waltham, MA).

Article Title: Bacterial Cytological Profiling Identifies Rhodanine-Containing PAINS Analogs as Specific Inhibitors of Escherichia coli Thymidylate Kinase In Vivo .
Article Snippet: A synthetic small molecule library consisting of ;1,800 compounds was obtained from the ChemBridge EXPRESS-pick library stock collection and screened in 96-well plates at 100mg/ml in Luria-Bertani (LB) medium to identify compounds active against the E. coli DtolC mutant.

Article Title: Targeting Troponin C with Small Molecules Containing Diphenyl Moieties: Calcium Sensitivity Effects on Striated Muscle and Structure Activity Relationship
Article Snippet: We focused on two small molecule libraries from ChemBridge, the EXPRESS-Pick Library and Core Library, and filtered each library with a cheminformatics approach as described in the section.



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